The Prestwick Chemical Library® contains 1200 small molecules, 100% approved drugs (FDA, EMEA and other agencies), thus it presents the greatest possible degree of
drug-likeliness. The active compounds were selected for their high chemical and pharmacological diversity as well as for their known bioavailability and safety in humans. The Prestwick Chemical Library ® was designed to reduce the risk of "low quality" hits, reduce the cost of the initial screening, and accelerate lead discovery.
The strategy we recommend is the "SOSA Approach" (C.G. Wermuth, J. Med. Chem. 2004, 47, 1303-1314). It consists of submitting to the target only a limited number of highly diverse drug molecules for which bioavailability and toxicity studies have already been performed and which have proven usefulness in humans. This initial screening will provide hits that will then be used as starting points for a drug optimization program which will rely on medicinal chemistry expertise. It can be noticed that, if the initial hit has sufficient affinity for the target, it could be immediately tested in patients.
The Prestwick Chemical Library® comes in two different presentations, either in DMSO solution and therefore ready for screening, or in powder form. In the first format, compounds are supplied at a precise 10 mM concentration in DMSO and at various volumes between 200ÁL to 1 mL, a special academic format is prepared on request. In the second packaging, compounds come as dry powder and are supplied in vials, each one containing 10 - 100 mg of substance.
The Prestwick Chemical Library® is provided with a standard data file (SDF) containing more than 50 fields in a hierarchical structure that can be individually customized (some data are pre-registered). A database in DB as well as in XLS format is offered as well. Therefore, each library is supplied with a CD-ROM containing structures, chemical names and smiles of the compounds of the library, as well as useful physicochemical and biological data, literature references and precautions.
For all the active substances of the Prestwick Chemical Library®, additional amounts up to 100mg can be provided at cost.
The Library is sold with "no strings attached" (i.e. no royalties or milestones are requested).